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While the FDA has approved several forms of semaglutide, it does not approve compounded versions

Weight Loss Clinical Trial Results In Phase 2 clinical trials: Participants receiving 12 mg experienced up to 24.2% average body weight loss at 48 weeks Additional studies reported up to 28.7% weight reduction at 68 weeks Higher doses (8 mg and 12 mg) demonstrated the most significant results These findings suggest Retatrutide may outperform current GLP-1 therapies and dual-agonist medications in terms of total weight loss

The program is designed to lay the groundwork for a longer-term Medicare GLP-1 coverage framework called the BALANCE Model but CMS has already delayed the 2027 Medicare Part D component of that model, and the full 2028 implementation depends on plan participation decisions during Medicare Open Enrollment 2026 (October 15 to December 7, 2026)

If youre unsure, discuss more with your provider