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Explicit description of solvent, counterions and thermal fluctuations on the level of multiscale simulation is computationally demanding and would not significantly change the results (Warshel and Levitt, Conclusion We have studied the reaction mechanism of dopamine autoxidation using quantum chemical methods, and shown that at the physiologic pH the rate-limiting step is the formation of a hydroxide ion

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Cell signalling can be disrupted by oxidative stress

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