GHS-R/Ghrelin Receptor Pathway (Ipamorelin) Ipamorelin activates the growth hormone secretagogue receptor (GHS-R1a), the same receptor targeted by endogenous ghrelin
Some research suggests that continuous GH secretagogue use can downregulate pituitary receptors over 1216 weeks, making periodic breaks beneficial
Why the Ipamorelin and Tesamorelin Blend Works: GHRH + GHRP Synergy Heres where the pharmacology gets exciting
J Clin Endocrinol Metab 96, E1228-36 (2011)
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