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5 Interestingly, the colon is a major site of gut bacterial fermentation, yielding high levels of short chain fatty acids (SCFAs, 70130 mmol l 1 )

It removes the dependency on conversion and reduces the likelihood of metabolic bottlenecks

This multi-pathway synergy helps maintain more youthful and elastic blood vessels, optimizes hemodynamics, balances lipid profiles, and strengthens overall cardiovascular resilience

Meanwhile, more than 12% of patients on the highest dose also experienced dysesthesia, which is an unpleasant nerve sensation observed in previous trials of the drug

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