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doi: 10.1038/s41419-020-03038-z 279 LiBLiNZhangLLiKXieYXueMet al

G) Bar graph representing an increase in the number of spines following treatment with vehicle, Nlel-AnglV or Dihexa, ensuring health of the neurons (***=P 0.05

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In another report, a 26week treatment with the GLP1R/GIPR dual agonist LY3298176 (Tirzepatide, Eli Lilly), showed significant reduction in A1c in an incremental, dosedependent manner (4 doses from 1 mg to 15 mg, A1c reduction from 1.06% to 1.94% respectively)

TABLE 2 Compound ( 10 ' 12 M) HGF Mimetic Activity N- heptanoyl-Tyr-Ile-(6) aminohexamide N- hexanoyl-Tyr-Ile-(6) aminohexamide ++++ N- pentaanoyl-Tyr-Ile-(6) aminohexamide _j N- butanoyl-Tyr-Ile-(6) aminohexamide +++ N- propananoyl-Tyr-Ile-(6) aminohexamide ++ N- acetanoyl-Tyr-Ile-(6) aminohexamide + N- benzoyl-Tyr-Ue-(6) aminohexamide + N- hexanoyl- (CH 2 -NIT 2 )-Tyr-Ile-(6) aminohexamide +++ Cell culture