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Key points Leg cramps (especially calves and feet) are most commonly reported Nighttime cramps and post-exercise cramps appear most frequently Duration typically ranges from seconds to minutes per episode Intensity varies from mild discomfort to painful spasms that wake patients from sleep Managing muscle cramps Most Mounjaro-related muscle cramps can be effectively managed with simple strategies

Qualitative data assessment The qualitative data based on the Cochrane risk of bias assessment tool were presented in Table 2

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[141] Although there have been sporadic synthetic efforts since 1972, [140] the EschenmoserWoodward synthesis remains the only completed (formal) total synthesis