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In contrast, a coffee enema goes further: Therefore, it is considered a therapeutic tool in integrative medicine settings

doi: 10.1016/j.envint.2025.109391 11 SunSShenJJiangJWangFMinJ

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Sermorelin stimulation preserves negative feedback loops mediated by IGF-1, somatostatin, and other factors, creating a self-limiting system that helps prevent excessive GH production and associated risks like acromegaly-like symptoms, severe insulin resistance, or fluid retention