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This is mechanistically distinct from the appetite effect and explains why tirzepatide produces greater fat-mass loss relative to lean-mass loss compared to GLP-1 monotherapy in DEXA substudy data from SURPASS-3 [24]
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The exclusion criteria were: females who were pregnant or experiencing a menstrual period, type 2 diabetes treated using an insulin regimen, malignancy, hematopathy, active tuberculosis, peptic ulcer with gastric bleeding, binge-eating disorder, psychiatric disease, congestive heart failure, clinically relevant renal or hepatic insufficiency, unstable coronary artery disease, cancer or a history of cancer
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