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The study was conducted in accordance with the ethical principles of the Declaration of Helsinki and it was approved by the Ethics Committee of the Hospital Universitario de La Princesa

Data analysis employed the random-effects model, presenting odds ratios (OR) with 95% confidence intervals (CI)

Back Pi-Sunyer, X, Astrup A, Fukuoka, K, et al (2 July 2015) 'Obesity and prediabetes NN8022-1839 study group

Drug Interactions Several common medications reduce B12 absorption: Metformin (diabetes) significant reduction in B12 absorption Proton pump inhibitors (Omeprazole, Pantoprazole) reduce stomach acid needed for absorption H2 blockers (Ranitidine, Famotidine) similar effect to PPIs Colchicine (gout) may reduce B12 absorption If you take any of these medications long-term, B12 supplementation is strongly recommended

Uses: Helps lighten and brighten skin, reduce dark spots and pigmentation, provide antioxidant protection, support detoxification, boost immunity, and promote healthy, radiant skin.