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Importantly, SMARRT included management of chronic conditions known to contribute to AD/ADRD risk (e.g., hypertension, diabetes), highlighting opportunities to better integrate personalized AD/ADRD, cardiovascular, and metabolic disease prevention

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Peak plasma concentrations may be markedly delayed following acute overdose [1114]

Alcohol makes this problem worse in two ways: it directly worsens the toxic effects of GHB, and it impairs the judgment needed to dose carefully or recognize early warning signs