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Since polyphenols can act as PAINS in biochemical assays (autofluorescence, redox cycling, aggregation, metal chelation), in-vitro hits without orthogonal validation were downgraded

Further, nanoagent (Nano-PT) composed by self-assembly of H 2 S activated small molecules has been reported for PTT consisting of BODIPY core and hydrophilic tail [98]

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