Geriatr Gerontol Int 20(2):97100
Moreover, studies have shown that certain drugs and integrative interventions, such as the staple antidiabetic medication metformin and the natural phytochemical curcumin (found in the spice turmeric), may help overcome chemoresistance and sensitize some cancers to the toxic effects of chemotherapy (Soritau 2011
In addition, the Connectivity Map gene profiling software developed by the Broad Institute, showed that out of several thousand biological molecules, the naturally occurring peptide glycyl-L-histidyl-L-lysine (GHK), in its Cu-bound form prevented impaired TGF1 signaling [4], a pathway associated with A deposition and neurofibrillary tangle formation [5]
Acknowledgments This study received financial support from Fundao de Amparo a Pesquisa de Gois (FAPEG), Coordenao de Aperfeioamento de Pessoal de Nvel Superior (CAPES), and Conselho Nacional do Desenvolvimento Cientfico e Tecnolgico (CNPq)
Nogueira, Maria Luiza Caldas, Sfora, Mauricio Luis, Leme, Adriana Franco Paes, Pauletti, Bianca Alves, de Oliveira, Paulo Sergio Lopes, Honorato, Rodrigo Vargas, King, Glenn F., Filho, Frederico Jos Gueiros and de Mattos Zeri, Ana Carolina (2016)
