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Some studies suggest splitting the dose into two smaller amounts for better efficacy

Gronwald and Plaisance, 1998): X-SG (the glutathione conjugate) can then be transported into and sequestered by the vacuole (Li et al, 1995

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However, in OA, M2 numbers are limited and may shift toward an M1-like phenotype under sustained inflammatory stimuli, reducing their capacity to maintain iron homeostasis (109, 110).Together, these insights support the hypothesis that iron metabolism in M1 macrophages not only contributes to ferroptosis susceptibility in OA, but also represents a potential immunometabolic checkpoint for therapeutic intervention

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