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aeruginosa strains have more 8-oxoGua upon exposure to polymorphonucleates (PMN) and this mechanism is proposed to be linked to an increased antibiotic resistance

the evidence base is four separate single-compound literatures

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The most critical limitation was that the number of participating patients was not sufficiently large to generalize these results and apply them to real clinical practice and that clinical data and sera samples from the time of diagnosis were used retrospectively