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107,108 In ME2-unexpressed gastric cancer cells, its isoenzyme ME1 is upregulated to replenish intracellular NADPH and promotes cell survival under glucose starvation and anoikis

demonstrated that intentional weight loss significantly improved the response of obese PsO patients to low-dose cyclosporine ( Collectively, these data highlight the importance of integrating metabolic health into early therapeutic strategies for PsA, particularly in individuals at high risk of disease progression or in those presenting with subclinical musculoskeletal involvement

PMID: 41084392 Phytomedicine Sarmentosin promotes USP17 and regulates Nrf2-mediated mitophagy and cellular oxidative stress to alleviate APAP-induced acute liver failure

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Gastrointestinal effectsincluding mild nausea or reduced desire for certain foodsoften appear alongside appetite changes in the first 12 weeks