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In parallel, aging microglia undergo a proinflammatory phenotypic shift, driven in part by the downregulation of TREM2 and impaired CX3CL1-CX3CR1 signaling [91]

doi: 10.3389/fphys.2026.1826699 Received 09 March 2026 Revised 02 April 2026 Accepted 09 April 2026 Published 28 April 2026 Volume 17 - 2026 Edited by Satoko Shinjo, University of Padua, Italy Reviewed by Alejandra Tomas, Imperial College London, United Kingdom Emily Walker, Wayne State University, United States Updates Copyright 2026 Cruz, Puebla-Huerta, Troncoso, Silva-Pavez, Hidalgo-Fadic and Ahumada-Castro

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