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Through direct binding to presenilin enhancer 2 (PEN2) on the lysosomal membrane, metformin inhibits v-ATPase via interaction with ATP6AP1, triggering recruitment of the AXIN-LKB1 complex to the lysosome (Ma et al., 2022

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Acute insults often cause multi-level damage including structural damage, metabolic stress and impairment of molecular homoeostasis, which trigger widespread homoeostatic failure

Marine Polysaccharides Carrageenans enhance eryptosis and alter lipid order of cell membranes in erythrocytes