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While the in vivo evidence supporting the osteogenic potential of NAC is promising, the inconsistency in its effects across different signaling pathways suggests a research gap

The effect of simvastatin on gene expression of low-density lipoprotein receptor, sterol regulatory element-binding proteins, stearoyl-CoA desaturase 1 mRNA in rat hepatic tissues

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Additional limitations include the potential involvement of compensatory mechanisms, such as upregulation of alternative growth factors or inflammatory mediators, which may influence muscle function independently or synergistically