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It begs the question why TSP1 produced by other cell types is insufficient to correct the phenotype of the PF4 C re Thbs1 flox KO mice

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Nicotinamide N-methyltransferase (NNMT) is a cytosolic enzyme that catalyzes the methylation of nicotinamide using S-adenosylmethionine (SAM) as a methyl donor, producing 1-methylnicotinamide (1-MNA) and S-adenosylhomocysteine (SAH)