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Insurance companies operate for a profit, so drug costs significantly impact coverage

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Emerging evidence suggests that GLP-1 medications can also activate areas of the brain involved in reward, motivation, and impulse controlthe same systems affected by substance use and addiction

Safety really comes down to proper dosing and patient selection by a licensed provider. A 2025 review that assessed the safety profiles of both drugs found that the most common adverse effects are the same for both tirzepatide and semaglutide, namely, nausea, vomiting and diarrhea

Understanding why the dosage chart exists and how to use it properly can make a significant difference to both comfort and results