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Ipamorelin : 2nd-generation GHRP, highly selective for GHS-R1a, no significant impact on cortisol or prolactin the current darling of modern protocols GHRP-6 : first generation, potent but triggers marked hunger (ghrelin-like action on the arcuate nucleus) and slight prolactin/cortisol elevation Hexarelin : most potent on acute GH release, but rapid GHS-R1a desensitization after prolonged use and more pronounced cortisol elevation Key point: GHRPs add an amplifying signal that potentiates GHRH, but chronic monotherapy triggers receptor down-regulation

doi: 10.1016/j.cell.2025.05.043, 161 ZhangQ.DelessaC

While some women notice improvements sooner, 12 weeks gives your body ample time to adjust and establish new and healthy patterns

For an in depth look into this therapy see my article on Platelet-Rich Plasma for Tennis Elbow The downsides are that it is often expensive, (particularly in affluent urban areas in the US) Its typically not covered by insurance, and it can be quite painful during and for days after the procedure

PMID 11266437