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[4] [15] Optimal levels remain debated, though most guidelines suggest maintaining levels above 50 nmol/L

At the GIPR, tirzepatide triggers Gs-mediated cAMP production in adipocytes and pancreatic beta cells, enhancing insulin secretion, improving fat storage efficiency in subcutaneous depots, and increasing lipid buffering capacity

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5 Dysfunction of metabolic homeostasis is associated with multiple diseases, highlighting the importance of the liver in maintaining the overall metabolic balance