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Implications for Healthspan and Mortality Reduction Overall, individuals with SMIs account for a disproportionate share of years of life lost and disability-adjusted life years

195,196,197 UC patients usually have an imbalance in the abundance of beneficial bacteria and harmful bacteria in the intestinal microbiota, which affects the intestinal microenvironment and results in damage to intestinal epithelial cells and the intestinal barrier

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Bacterial counts can reach 10^5 CFU/mL (colony-forming units per milliliter) in water that still looks perfectly clear

Balthasar N, Dalgaard LT, Lee CE, Yu J, Funahashi H, Williams T, et al