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While BW reduction likely contributes to improvements in conditions, such as hepatic steatosis or sleep apnea, GLP-1 RAs may also exert direct disease-specific effects, particularly through central mechanisms implicated in neurodegeneration and addiction [39]

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Increasing energy expenditure therefore makes it possible to destock fats which will be transported by Carnitine to the mitochondria to be transformed into energy

Mietlicki-Baase et al

Cardiac-specific LRP6 knockout induces lipid accumulation through Drp1/CPT1b pathway in adult mice