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In order to test a possible effect of intracellular glutathione synthesis in such a process, buthionine sulfoximine (BSO), a specific the inhibitor of gamma-glutamylcysteine synthetase, was used to block the first step of intracellular glutathione synthesis

Sep 30 2019;28(153)doi:10.1183/16000617.0083-2019 Ramar K, Dort LC, Katz SG, et al

This association is what gives some researchers pause about levocarnitine supplementation

In cases where the deficiency is due to an underlying condition, treating the underlying cause may also be necessary