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Glutathione S-conjugates are usually sequestered by distinct ABC transporters from the cytosol into the vacuole for degradation, although breakdown of glutathione, oxidized glutathione and glutathione S-conjugates also happens outside the vacuole 56

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In human cell culture, Jakubowski (1997) showed that the thiolactone produced by an altered homocysteine metabolism may be incorporated into cellular and extracellular protein through lysine acylation by its activated carboxyl group

Res Commun Chem Pathol Pharmacol 53(1):93104 Endo A, Watanabe T (1988) Analysis of protective activity of N-acetylcysteine against teratogenicity of heavy metals

However, formal pharmacoeconomic analyses comparing these agents to standard drugs are currently lacking and should be prioritized in future research