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assessed the impact of semaglutide treatment (0.5 1 mg weekly) over 12 to 36 months on weight reduction and glycemic control in four adults with PWS with concomitant diabetes, all of whom also started growth hormone replacement approximately 3 to 5 years before semaglutide initiation

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The GLP-1 analogues liraglutide and semaglutide reduce atherosclerosis in ApoE-/- and LDLr-/- mice by a mechanism that includes inflammatory pathways

Yes, where appropriate

If nausea has prevented you from reaching therapeutic doses , the B12 component may help you progress through the titration schedule more comfortably