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Reported side effects in available research and clinical use include fatigue, headaches, nausea, and injection site irritation generally mild, but again, incompletely characterized over long-term use

doi: 10.1001/archinternmed.2010.348

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When patients present with concerning symptoms whilst taking B12 supplements, alternative diagnoses should be considered, including allergic reactions to supplement excipients, interactions with other medications, or coincidental illness

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