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This effect is frequency-specific

[69] developed a cartilage-targeted single-chain human antibody fragment (CaAb) and fused this fragment to IGF-1

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Mechanistically, this combination therapy modulates key mediators such as thromboxane A2 (TXA2) and prostacyclin (PGI2), including their downstream effector cyclooxygenase-2 (COX-2), thereby contributing to its antithrombotic properties

During disease progression, circulating immune cells such as monocytes and lymphocytes infiltrate the synovial membrane, triggering a cascade of pro-inflammatory signals that manifest clinically as joint swelling