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The SELECT trial established cardiovascular risk reduction in overweight adults without diabetes, while the STEP HFpEF program showed symptomatic improvement in heart failure with preserved ejection fraction [2]

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While oral bioavailability is lower than subcutaneous administration, these studies established that even high oral doses maintained excellent safety profiles, though higher doses (54 mg) were associated with increased gastrointestinal discomfort

Under the terms of the deal, the pharmaceutical giant will pay Gubra $350 million upfront

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