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1 A second theory relates to dopaminergic dysfunction, based on the effectiveness of dopamine agonists in relieving RLS symptoms and the high prevalence of RLS in patients treated with antipsychotics that block dopamine

Proc Natl Acad Sci USA 104(29):1201712022 Fernandez-Marcos PJ, Auwerx J (2011) Regulation of PGC-1, a nodal regulator of mitochondrial biogenesis