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A decrease in PaO 2 , without a change in A-a gradient is caused by hypo-ventilation whereas a decrease in PaO 2 with an increase in A-a gradient indicates ventilationperfusion mismatch 15,16,82

General anesthesia activates the mitochondrial unfolded protein response and induces age-dependent, long-lasting changes in mitochondrial function in the developing brain

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When protein intake is inadequate, nail growth slows and nails become thin, brittle, and prone to breaking

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