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6, our data showed that MCC950 was significantly blocked PASMCs pyroptosis by inhibiting NLRP3, GSDMD, Caspase 1, IL-18, and restrained vascular remodeling by affecting PCNA, Caspase3, MMP2, AMPK1, while thromboinflammation factor heat shock protein 47 (HSP47) expression was not affected, indicating that HSP47 is the upstream of NLRP3 inflammasome, and C10:2 could modulate pulmonary vascular remodeling via C10:2/HSP47/NLRP3 axis

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