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Pharmacokinetic assay of NP4 The pharmacokinetics of Ru(II)-OH and NP4 (Ru 800 , 200 L) were evaluated in healthy female BABL/c mice (5 weeks)

doi: 10.1016/S0925-4439(01)00025-4 5 CarrellRW

One-quarter tablet (200 micrograms) Actifolate One-quarter tablet Intrinsic B12/folate (200 mcg of folate as folic acid, 5-methyl tetrahydrofolate, and 5-formyl tetrahydrofolate (folinic acid or leucovorin), 125 mcg of vitamin B12 as cyanocobalamin, 22.5 mg of calcium, 17.25 mg of phosphorus, and 5 mg of intrinsic factor)

The regular vitamin D metabolic profiles illustrated with either wild-type mouse VDR or VDR null mice transgenic for the wild-type human VDR, but not the ligand binding-defective form of the protein, this suggests the essential roles of VDR on VD metabolism 25