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In metastatic pancreatic cancer patients treated with ganitumab and gemcitabine, higher circulating levels of IGF-1, IGF-2 or IGFBP-3 was associated with better response in Phase II trials [100], but stratifying patients based on these biomarkers did not translate into survival benefit in Phase III trials [52]

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Nodules or lumps: Injection creating small subcutaneous deposits