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Some studies have reported that the key molecule in oxaliplatin resistance is CDK1, which directly binds to and phosphorylates long-chain acyl-CoA synthetase 4 (ACSL4) and subsequently recruits E3 ubiquitin ligase, causing ACSL4 polyubiquitination, leading to the degradation of ACSL4 protein

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Elderly patients tend to have a greater frequency of decreased hepatic, renal, or cardiac function, and also have concomitant disease or receiving other drug therapy