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Since it does not affect hormone levels, insulin sensitivity, or appetite regulation, there is no rebound effect from discontinuation

Ren TH, Wu J, Yew D, Ziea E, Lao L, Leung WK, Berman B, Hu PJ et al (2007) Effects of neonatal maternal separation on neurochemical and sensory response to colonic distension in a rat model of irritable bowel syndrome

But I find in my anecdote, as you will, is it has been extremely safe

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