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In vitro studies using normal human epidermal keratinocytes revealed that treatment with glutathione amino acid precursors significantly increased both GSH and glutathione disulfide levels, leading to an improved GSH/glutathione disulfide ratio, which is a key indicator of cellular redox balance

We have found that both the closed and extended GSH conformations are present in human brain and the relative proportion of individual conformer peak depends on the specific selection of refocusing ON-pulse position in MEGA-PRESS pulse sequence