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The extent of reversibility remains uncertain, but consistent injections of B12 over a minimum of 12 months is recommended to optimize recovery

The ensuing negative feedback loop may involve not only EECs but also Paneth cells and intestinal intraepithelial lymphocytes, as these cells have been reported to express the receptor for GLP-1 (namely GLP-1R), and loss of GLP-1R increases the severity of DSS-induced intestinal injury8, 9

Interestingly, Western blotting demonstrated that GLP-1R activation further upregulated the ratio of p-Akt/t-Akt when compared to IL-1 group (Fig

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