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Evidence for performance benefit at high IV doses is mixed antioxidant effect is biologically plausible, but clinical outcomes data in athletes is limited

As a broad generalisation, the highest concentrations occur in neurons/brain, the eye, phagocytes and the adrenal gland which are tissues particularly exposed oxidative stress or, in the case of the adrenal gland, which house hormone synthesising 2-oxoglutarate-dependent dioxygenases

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Obesity leads to fat infiltration of various organs, and these fatty tissues produce many chemicals which cause dysfunction of these organs, including gallbladder

The disulfide within the active site is subsequently reduced through a glutathionylated intermediate by in total two molecules GSH leading to the release of glutathione disulfide (GSSG)