As of May 2025, the case remains pending, with no final judgment or settlement reported
Notably, key transcription factors (e.g., Nrf2 and HIF-1) act as critical regulatory checkpoints within this network: Nrf2 inhibits ferroptosis and inflammation by upregulating GPX4 and antioxidant enzymes, while HIF-1 exerts a context-dependent dual role, acutely mitigating ferroptosis via Nrf2 activation but promoting fibrosis and sustained ferroptosis when chronically stabilized
Animal experiments The high-stability reduced glutathione for injection is provided by Hubei people pharmaceutical Co., Ltd, and the special safety test research of the medicine is completed by Chengdouqi medicine non-clinical research Co., Ltd
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10.1046/j.1460-9568.2003.02725.x 293 TschpM.SmileyD