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Under intestinal ischemia-reperfusion, neutrophil extracellular trapping nets (NETs) are released, and NETs activate receptor-interacting protein kinase3 (RIPK3) by binding to Toll-like receptor 4 (TLR4), which phosphorylates FUNDC1, resulting in inhibition of mitophagy and the inability of the damaged mitochondria to be cleared promptly, triggering Mitochondria-dependent necrotic apoptosis, ultimately leading to necrotic apoptosis of intestinal epithelial cells [107]

Disponible en: Walter JH

JAMA (2022) 327:53445

You should also contact your physician immediately if you have severe bloating, stomach pain or constipation