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It is determined by a qualified healthcare professional based on factors such as nutrient deficiencies, health goals, and response to treatment

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However, observational studies suggest that whilst acute toxicity remains exceptionally rare, sustained very high levels of B12particularly from supplements or injectionsmay be associated with certain health concerns, though these are correlations rather than proven causal relationships

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[DOI] [PMC free article] [PubMed] [Google Scholar] 4.Ahmadi Ashtiani H.R., Bishe P., Lashgari N., Nilforoushzadeh M.A., Zare S