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They are not authorised by the MHRA for human administration, and retatrutide remains investigational pending Phase 3 completion [1] [unverified]

The study includes both the very early and prolonged periods

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What Current Evidence and Clinical Trials Tell Us The key published evidence is a 2023 Phase 2 RCT (Jastreboff et al.) showing substantial weight loss and predominantly mild-to-moderate GI side effects

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