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As a D-amino acid peptide, FOXO4-DRI is costly to synthesize, and a wrong amino acid at the binding site can sharply cut activity

The anti-inflammatory effects of different parameters were evaluated by quantifying mRNA expression levels of key pro-inflammatory factors (IL-1, IL-6, COX-2, and iNOS) via RT-qPCR

Ultimately, the choice of intervention may be guided by the clinical scenario, balancing immediacy of effect against durability

High-quality protein sources like eggs, lean meats, fish, and whey protein provide these essential building blocks

Meanwhile, mTORC1, in nutrient-rich conditions, activates forkhead box K1/2 (FoxK1/2) which counters Foxo3-induced activation of autophagy by restricting the acetylation of histone H4 and expression of critical autophagy genes [299]