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corroborated by Silverii 2025 RCT meta-analysis (OR 1.55) on a small absolute base

This interaction between the autonomic nervous system and connective tissue and the musculoskeletal system and the GI tract we haven't even gotten into that yet and the nervous system is just really so fascinating

Theres growing evidence that alternative sites of activity, like the gut microbiome, tissue-resident immune cells, and the gastrointestinal system, may potentially be significant in metformin efficacy (Thakkar et al., 2013

Its not classified as a controlled substance, but selling it as a health product violates Canadian law

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