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This mutant can still synthesize glutathione, but is not able to produce the inner membrane ABC-transporter CydDC that transports glutathione from the cytosol into the periplasm and hence suffers from reduced periplasmic glutathione levels (Mironov et al., 2020

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Both are early enough in development that the published endpoints are surrogates body weight, HbA1c, liver fat measured over trial-length follow-up

Conversely, gaining weight without adjusting thyroid medication may contribute to persistent hypothyroid symptoms and fatigue, sometimes with awareness of slow or forceful heartbeats

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