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10.1080/10495398.2023.2236660 10 BrownA

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Originally developed for diabetes treatment, Ozempic (semaglutide) and its higher-dose counterpart Wegovy have shown remarkable efficacy in weight reduction, offering new hope for those struggling with weight issues

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If this line of thinking is applied to the mesolimbic GLP-1R activation, it is plausible that while NAc GLP-1R activation is associated with a suppression of the dopamine signal, the VTA GLP-1R reduce reward behavior via another mechanism