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IDH1-dependent -KG regulates brown fat differentiation and function by modulating histone methylation

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Patients with ALD have reduced levels of MAT1 and a reduced hepatocyte methylation/CYP2E1 ratio

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Thrombus formation at sites of plaque rupture accounts for the majority of clinical events with acute occlusive luminal thrombosis causing myocardial infarction, unstable angina, sudden cardiac death, and stroke (168,169)