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They may not fully replace injectables, especially for patients requiring maximum weight reduction, but they could reshape early intervention, maintenance therapy, emerging market access, and primary care adoption

visible skin or hair changes, when they occur, typically build gradually over weeks to months rather than overnight

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[26] showed that liraglutide-dependent weight loss relies on its binding to GLP-1Rs located mainly in POMC/CART (cocaine- and amphetamine-regulated transcript) anorexigenic neurons in the ARC, but an indirect inhibitory effect of agouti-related peptide (AgRP) orexigenic neurons via -aminobutyric acid (GABA)-ergic signaling was also observed

[DOI] [PMC free article] [PubMed] [Google Scholar] 62.Bortolato A, Dor AS, Hollenstein K, Tehan BG, Mason JS, Marshall FH